Detection method of early gastric cancer
1. Laboratory
Markers of gastric cancer: gastric cancer cells to produce a
variety of substances in gastric juice, blood and other tissues has
been detected can be used as a marker of gastric cancer screening of
gastric cancer screening, such as a variety of enzymes and markers
derived from embryos.
Cancer Gene: p2lras is generally believed that high expression of
intestinal type gastric cancer, but in dysplasia, intestinal
metaplasia, tumor and normal mucosa in the vicinity of high expression
of both, so that the genes in gastric cancer occurred during the early
stages of work. APC gene deletion mutation is also common in the early
gastric cancer, and many occurred in undifferentiated gastric cancer.
In addition, p53 gene, CD44v6 gene expression and gastric cancer
occurrence and the biological behavior of gastric cancer and gastric
mucosa a high degree of dysplasia, early gastric cancer, advanced
gastric cancer specimens in turn increased the expression. Progression
of gastric cancer is a genetically modified variety of the results of
these gastric cancer-related genes on the genetic diagnosis of early
gastric cancer is of great significance, but the specificity to be
increased.
Gastric cancer monoclonal antibody: monoclonal antibodies the
diagnosis of early gastric cancer in gastric cancer is currently a
major topic. For example, monoclonal antibody MG7 on 1090 cases of
patients testing positive rate was 41.8%.
Gastric occult blood bead method: National survey shows that 23
thousand people, gastric occult blood positive rate was 12%, 581
patients were diagnosed as esophageal cancer and gastric cancer, 70% of
patients with pathological examination for the early and mid-cancer.
Specificity of this Act is not high, but the method is simple, subjects
can be repeated or for continuous dynamic observation of the
large-scale population surveys have greater value.
The probability of a computer model of gastric cancer screening:
census, according to local risk factors for gastric cancer in all its
elect a meaningful factor, to establish the probability of a
mathematical model to the data for each subjects entered into the
computer, via regression analysis, positive high-risk populations. If
the combination of this method of gastric cancer marker method can
improve detection rates.
2. Radiographically
Although the vast majority of lesions can be found, but the rate
of misdiagnosis remains high malignant. Stomach and imaging studies,
including double-contrast image, mucous membranes, like, filling, like,
oppression, as a variety of inspection methods. Can be found by
comparing the double-contrast, as with the mucous membrane lesions, as
can be clearly shown, oppression, like the right lower part of the
anterior wall of the stomach lesions appear particularly important,
four kinds of inspection methods can complement each other proved to
improve the detection rate of malignant lesions.
With the dual-phase helical CT and the clinical application of CT
simulation of gastroscopy, allowing imaging to detect the sensitivity
of early gastric cancer can be greatly enhanced. Based on current
statistics, CT diagnosis of early gastric cancer simulated gastroscopy
positive coincidence rate can reach 70%, the smallest can show mucosal
lesions of the diameter of about 1cm. However, the high cost of
surviving in the diagnosis of the problem, does not apply to the
census.
3. Endoscopy France
Early gastric cancer does not have specific clinical symptoms, so
for more than 40 years of age, there are clear symptoms of indigestion,
or in patients with pre-cancerous lesions and should be routine
gastroscopy. Compared with the imaging studies, endoscopic significant
advantages. It can be direct observation of pathological changes,
visual field width, to distinguish strong, biopsy with high accuracy.
4. Endoscopic Ultrasonography
Increased the scope of endoscopic diagnosis, while reducing the
ultrasonic probe and the distance from the target organ, so that higher
resolution ultrasound. EUS examination of early gastric cancer and
advanced gastric cancer up to 90% accuracy rate to determine the depth
of cancer types as well as the infiltration rate of accuracy up to 70 ~
80%. EUS can also help discover whether the regional lymph node
metastasis of early gastric cancer.
In conclusion, gastric cancer early detection and early diagnosis
is the basis for early treatment, but also to reduce a key element in
gastric cancer mortality. In the diagnosis of technical means rising
today, is entirely want to do a good job of early gastric cancer
screening work.
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